Additional file 1 of Neurodegenerative disease-associated microRNAs acting as signaling molecules modulate CNS neuron structure and viability

Additional file 1: Supplementary Fig. S1. Extracellular miR-92a-1-5p, miR-124-5p, let-7b, and loxoribine induce neuronal loss. Supplementary Fig. S2. Exposure of neurons to extracellular miR-92a-1-5p and miR-124-5p triggers concordant gene expression. Supplementary Fig. S3. Exposure of neurons to extracellular miR-92a-1-5p and miR-124-5p modulates transcriptional pathways. Supplementary Fig. S4. Extracellular miR-92a-1-5p and miR-124-5p induce inflammatory cytokine expression in microglia. Supplementary Fig. S5. Human cortical organoids express TLR7 and TLR8. Supplementary Fig. S6. Dendritic and axonal degeneration index of iNeurons exposed to miR-9-5p and miR-501-3p. Supplementary Table S1. Primer sequences for qPCR. Supplementary Table S2. Summary of the effects induced by extracellularly delivered miR-92a-1-5p and miR-124-5p in primary neurons and adult mouse brain. Supplementary Table S3. List of genes deregulated in common after 6h and 5d exposure of C57BL/6 cortical neurons to miR-92a-1-5p, miR-124-5p, or Mut.oligo. Supplementary Table S5. Summary of the effects induced by extracellularly delivered miR-9-5p and miR-501-3p in human iNeurons. Supplementary Table S6. Published datasets that were analyzed in this study.