Chemical composition and anticancer potential of water extracts derived from ground powder of Thai germinated brown rice (<i>Oryza sativa L.</i>)

Powdered germinated Thai rice (<i>Oryza sativa L.</i>) is widely utilised as a dietary supplement to support health and prevent diseases. This study investigated the bioactive compound profile of water extracts from beverage powder made from Thai germinated brown rice (GBRE) and assessed its anticancer effects on cholangiocarcinoma, lung cancer, and liver cancer cell lines. Proton nuclear magnetic resonance (1H-NMR) revealed 23 metabolites, including amino acids, sugar, phenolic compounds and nitrogenous compounds. Additionally, GBRE exhibited anticancer properties by effectively inhibiting cancer cell growth, inducing cell cycle arrest, and reducing cell migration. Our findings highlight the nutritional benefits and anticancer potential of germinated brown rice powder in impeding cancer cell progression. This study demonstrates the nutritional benefits and anticancer effects of germinated brown rice powder in inhibiting cancer cell progression. Incorporating germinated brown rice powder for a nutraceutical supplement can be served as a potential strategy for cancer prevention or therapeutic intervention.