Antibacterial <i>ent</i>-trachyloban-19-oic acid and other constituents from <i>Croton kinondoensis</i> G.W. Hu, Ngumbau &amp; Q.F. Wang

Phytochemical analysis of the twigs and leaves of <i>Croton kinondoensis</i>, endemic to Kenya, yielded known compounds 3-(3′,4′-dimethoxyphenyl)-prop-1-ene (<b>1)</b>, 3-(3′,4′-dimethoxyphenyl)-propenal (<b>2</b>), lupeol (<b>3</b>) and <i>ent</i>-trachyloban-19-oic acid (<b>4</b>), and a tentatively new <i>ent</i>-clerodane diterpenoid, crotokinondoenolide (<b>5</b>). <i>ent</i>-Trachy­loban-19-oic acid (<b>4</b>) showed good activity against a panel of drug-resistant strains of <i>Staphylococcus aureus</i> and <i>Enterococcus</i> spp with MIC ­values of 25 <i>µ</i>g/mL.