Associations Between Cannabis Messaging and Derived Psychoactive Cannabis Product Perceptions, Use, and Use Intentions Among a Sample of US Young Adults

Since the 2018 Agricultural Improvement Act, derived intoxicating cannabis products (DICPs) emerged as largely unregulated products; meanwhile, traditional cannabis use has increased. To inform effective prevention, research is needed to assess differences in motives for using cannabis <i>only</i> versus <i>both</i> cannabis and DICPs, as well as use-related consequences. We analyzed survey data (June–November 2023) from 4,031 US young adults ages 18–34 (average age = 26.9; 63.9% White; 59.0% female; aiming for ∼50% past-month cannabis use). The analytic sample included participants reporting past-month cannabis use (<i>n</i> = 1,968). Two cross-sectional mediation models were conducted to examine: 1) cannabis use motives (social/cognitive enhancement and coping) in relation to use-related consequences (psychophysiological and sociobehavioral) <i>via</i> use category (cannabis-only vs. cannabis-DICP co-use) and 2) consequences in relation to use category <i>via</i> use motives. Overall, 54.4% reported cannabis-only use and 45.6% reported cannabis-DICP co-use. Greater enhancement and coping motives were associated with cannabis-DICP co-use (vs. cannabis-only use). Regarding Model #1, lower cannabis coping motives and cannabis-DICP use (vs. cannabis-only use) were associated with greater psychophysiological and sociobehavioral consequences, and the associations between coping and enhancement motives and psychophysiological and sociobehavioral consequences were indirectly mediated <i>via</i> cannabis-DICP co-use. For Model #2, lower psychophysiological and greater sociobehavioral consequences were associated with greater coping and enhancement motives, greater sociobehavioral consequences was associated with higher odds of cannabis-DICP co-use (vs. cannabis-only use), and psychophysiological and sociobehavioral consequences were indirectly associated with cannabis-DICP co-use through enhancement and coping motives. Considering the risks associated with cannabis and DICP use, future intervention and prevention efforts should focus on the observed associations to reduce risk. DICP = derived intoxicating cannabis productWe analyzed 2023 data among 1,968 US young adults with past-month cannabis use; over half (54.4%) reported cannabis-only use; 45.6% reported cannabis-DICP co-use.Associations between motives and consequences were mediated <i>via</i> cannabis/DICP use.Consequences were indirectly associated with cannabis-DICP use through motives.Future efforts should focus on the observed cyclical associations to reduce risk. We analyzed 2023 data among 1,968 US young adults with past-month cannabis use; over half (54.4%) reported cannabis-only use; 45.6% reported cannabis-DICP co-use. Associations between motives and consequences were mediated <i>via</i> cannabis/DICP use. Consequences were indirectly associated with cannabis-DICP use through motives. Future efforts should focus on the observed cyclical associations to reduce risk. Findings from a cross-sectional mediation study.