A rare glisoprenin analogue from an endophytic fungus <i>Gliocladium</i> sp. F1

Glisoprenins are unique fungal polyisoprenepolyols with nine isoprene units from <i>Gliocladium</i> spp. Herein, glisoprenin G (<b>1</b>), a new member of glisoprenins group, along with a biosynthetically related known analogue glisoprenin F (<b>2</b>), were isolated and identified from an endophytic fungus, <i>Gliocladium</i> sp. F1, harboured in the roots of the Chinese medicinal plant <i>Mahonia fortunei</i>. The chemical structure of <b>1</b> showed the unusual loss of two isoprene carbon atoms and was determined by HRMS and NMR data. Compounds <b>1</b> and <b>2</b> showed moderate cytotoxic activity.