Additional file 1 of Aging-dependent YAP1 reduction contributes to AD pathology by upregulating the Nr4a1-AKT/GSK-3β axis

Additional file 1. Figure S1. The Hippo signaling pathway was activated in the hippocampal neurons of aged C57BL/6J mice. Figure S2. The Hippo signaling pathway was activated in the hippocampal neurons of SAMP8 mice. Figure S3. Knockdown of YAP1 in C57BL/6J mice resulted in increased p16 in the hippocampus. Figure S4. overexpression of YAP1 led to a reduction of p16 in the hippocampus of SAMP8 mice. Figure S5. Nr4a1 was required for YAP1 deficiency to induce cognitive impairment and neuronal senescence.