Additional file 1 of Visceral adipose tissue area and proportion provide distinct reflections of cardiometabolic outcomes in weight loss; pooled analysis of MRI-assessed CENTRAL and DIRECT PLUS dietary randomized controlled trials

Additional File 1: Methods S1: Exclusion criteria of the CENTRAL and DIRECT PLUS trials. Methods S2: Magnetic resonance imaging. Methods S3: Clinical parameters and laboratory methodology. Results S1: Cutoff values for metabolic syndrome and diabetes at baseline. Table S1: Baseline, end of intervention, and changes in key metabolic and adiposity variables. Table S2: Baseline characteristics of the CENTRAL and DIRECT PLUS clinical trials participants across sex-specific deciles of visceral adipose tissue proportion. n = 572 participants. Fig. S1: Baseline visceral abdominal adipose tissue area and proportion across various characteristics; Heatmap of Kendall’s tau correlations. Table S3: Visceral adiposity phenotypes of similar and opposite sex-specific visceral adipose tissue area and proportion medians. N = 553. Table S4: Post hoc analysis of visceral adiposity phenotypes of similar and opposite sex-specific visceral adipose tissue area and proportion medians. N = 553. Table S5: LASSO developed models for baseline VAT area. Table S6: LASSO developed models for baseline VAT proportion. Table S7: LASSO developed models for VAT area relative change. Table S8: LASSO developed models for VAT proportion relative change. Table S9: Participants’ characteristics in the training and testing data sets for baseline VAT area model development. Fig. S2: LASSO linear regression models of baseline and change VAT area and proportion (men only). Fig. S3: LASSO linear regression models of baseline and change VAT area and proportion while accounting for physical activity. Fig. S4: LASSO linear regression models of baseline and change VAT area and proportion while accounting for physical activity (men only). Fig. S5: LASSO linear regression models of baseline and change VAT area and proportion for clinical practice application. Fig. S6: LASSO linear regression models of baseline and change VAT area and proportion for clinical practice application (men only).