Efficient synthesis and <i>in vitro</i> biological activity of some novel thiazolopyrimidines and pyrazolopyrimidines via a microwave-assisted one‑pot three component reaction

In our present work, a novel group of desirable substances, thiazolopyrimidines <b>5a–f</b>, pyrazolopyrimidines <b>8a–f</b>, or pyridobenzimidazoles <b>10</b> and <b>11</b> have been produced with good to superior results by the one pot three component method of molecules <b>1a</b> or <b>1b</b> derivatives, DMF-DMA, and various arylthiazol-2-amines, 5-aminopyrazoles, or acetonitrile derivative <b>9</b> in pyridine under microwave irradiation at 130 °C for 120 min. This strategy is characterized by ease of use, quick reaction, and moderate reactions. All molecules were assessed for their antimicrobial potential against pathogenic organisms. The pyrazolopyrimidine analogue <b>8f</b> illustrated the best antimicrobial actions with Minimal inhibitory concentration values varying between 2.48 and 37.15 μM. The spectral results were used to ascertain the desired substances.