Bioactive phytochemicals, antioxidant potential, and anti-<i>Candida</i> activities of <i>Chamaecytisus drepanolobus</i> (boiss.) Rothm

Herein, HPLC-MS/MS was used to identify various compounds in the ethanol extract of the <i>Chamaecytisus drepanolobus</i> plant. The anti-<i>Candida</i> and antioxidant activities of the plant extract were also evaluated. <i>Candida guilliermondii</i> showed the largest inhibition zone (12.45 ± 0.02 mm), while <i>Candida tropicalis</i> (8.20 ± 0.01 mm) and <i>Candida famata</i> (8.30 ± 0.1 mm) exhibited the smallest inhibition zones. The minimum inhibitory concentration (MIC) for all tested <i>Candida</i> spp. strains fell in the range of 31.25–61.5 μg/mL for inhibition zone diameters ranging from 8.2 to 12.17 mm. The antioxidant activity of the ethanol extract (IC₅₀: 0.2002 mg/mL) is notable and slightly higher than that of the standard BHT, demonstrating the antioxidant potential of <i>C. drepanolobus</i>. Compositional analysis of the ethanol extract revealed high concentrations of quinic acid, malic acid, gallic acid, and cosmosiin (1925.63, 1471.05, 140.31, and 133.85 µg analyte/g extract, respectively), the compounds responsible for the plant’s antiradical and antifungal properties.