Additional file 1 of Optimizing midlife metabolic syndrome thresholds for dementia: a prospective study of two UK population-based cohorts

Supplementary Material 1: Additional File 1: Table S1. Comparison of characteristics of participants included and excluded from the analyses in the Whitehall II and UK Biobank cohort studies. Table S2. Model fit statistics of the linear and restricted cubic spline models for the association of MetS and its components with incident dementia. Table S3. Comparison of the original and revised definition of MetS in the association with incident dementia in the Whitehall II and UK Biobank cohorts using inverse probability weighting to account for missing data. Table S4. Comparison of the original and revised definition of MetS in the association with incident dementia in the Whitehall II and UK Biobank cohorts excluding prevalent cases of CVD at baseline from the analyses. Table S5. Comparison of the original and revised definition of MetS in the association with incident dementia in the UK Biobank cohort, stratified by sex. Figure S1. Flow chart of sample selection in the Whitehall II and UK Biobank cohort studies. Figure S2. Associations between MetS components and incident dementia in the Whitehall II study. Figure S3. The MetS scale (scale 0 to 5) modelled as a continuous variable for the association of the number of metabolic syndrome components with incident dementia in the Whitehall II study. Figure S4. The MetS scale (scale 0 to 5) modelled as a continuous variable for the association of the number of metabolic syndrome components with incident dementia in the UK Biobank study.