Additional file 6 of Antibody-based delivery of interleukin-2 modulates the immunosuppressive tumor microenvironment and achieves cure in pancreatic ductal adenocarcinoma syngeneic mice

Supplementary Material 6: Supplementary Fig. 6. DEA showed increased immune activation of L19-IL2 compared to FOLFOX. a) Volcano plot showing the genes differentially expressed (log2 Fold Change ≦ -1.5 ≧ 1.5, FDR < 0.05) in the comparison between L19-IL2 treated and FOLFOX treated mice. b) Dot plot showing main activated and suppressed pathway in L19-IL2 treated mice (top 10 pathways). c) Network plot showing the consistent upregulation of genes involved in immune response (FDR < 0.05).