Additional file 1 of Evaluating metabolome-wide causal effects on risk for psychiatric and neurodegenerative disorders

Additional file 1. S1: Description of genetic correlations between neuropsychiatric disorders; Fig S2: Heatmap of genetic correlations between neuropsychiatric disorders, calculated using linkage disequilibrium score regression (LDSC) within GenomicSEM; Fig. S3: Forest plots of IVW-MR estimates for the effect of significant polygenic metabolites on unadjusted and BMI, waist-to-hip ratio and educational attainment adjusted neuropsychiatric outcomes; Fig S4: Simplified metabolic pathway from linoleic acid (LA) to arachadonic acid (AA) derived from KEGG pathway hsa00591; Fig S5: Simplified metabolic pathway for sphingomyelin and ceramide metabolism from KEGG pathway hsa00600.