Two new cadinane-type sesquiterpene glycosides from <i>Dendrobium findleyanum</i>

Two novel and two previously identified cadinane-type sesquiterpene glycosides, findleyanosides E-F (<b>1</b>-<b>2</b>), balanoindicoside B (<b>3</b>) and pumilaside C (<b>4</b>), were extracted from the <i>Dendrobium findleyanum</i> stems. The establishment of structures was mainly conducted <i>via</i> spectroscopic techniques and by comparing with literature data. Electronic circular dichroism (ECD) computations helped determine the absolute configuration of the novel molecules. All molecules exhibited moderate cytotoxic effects against A-549 human tumour cell lines, with IC<sub>50</sub> values of 15.52, 17.68, 13.85 and 16.64 <i>μ</i>M, respectively.

Publication Details

Journal
Figshare
Published
2025-01-01
DOI
https://doi.org/10.6084/m9.figshare.29891165.v1
Primary Topic
Machine Learning in Bioinformatics
Type
article
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article

Two new cadinane-type sesquiterpene glycosides from Dendrobium findleyanum

Figshare
Machine Learning in Bioinformatics
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Two new cadinane-type sesquiterpene glycosides from Dendrobium findleyanum

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Abstract

Two novel and two previously identified cadinane-type sesquiterpene glycosides, findleyanosides E-F (<b>1</b>-<b>2</b>), balanoindicoside B (<b>3</b>) and pumilaside C (<b>4</b>), were extracted from the <i>Dendrobium findleyanum</i> stems. The establishment of structures was mainly conducted <i>via</i> spectroscopic techniques and by comparing with literature data. Electronic circular dichroism (ECD) computations helped determine the absolute configuration of the novel molecules. All molecules exhibited moderate cytotoxic effects against A-549 human tumour cell lines, with IC<sub>50</sub> values of 15.52, 17.68, 13.85 and 16.64 <i>μ</i>M, respectively.

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Machine Learning in Bioinformatics
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Two new cadinane-type sesquiterpene glycosides from <i>Dendrobium findleyanum</i> · Figshare (2025) | TGRS Research Map | TGRS