Neuroprotective Effects of Intermittent Fasting in Animal Models of Peripheral Neuropathy: A Systematic Review of Prevention and Disease Progression

This systematic review protocol outlines a comprehensive evaluation of the neuroprotective effects of intermittent fasting (IF) in animal models of peripheral neuropathy. Peripheral neuropathy, a debilitating complication of metabolic disorders (e.g., diabetes) and chemotherapy, lacks universally effective treatments. Preclinical evidence suggests IF may mitigate neuropathy progression by modulating autophagy, oxidative stress, and mitochondrial function, but findings remain fragmented across heterogeneous models.<b>Objectives:</b>Assess IF’s efficacy in preventing or slowing neuropathy progression using behavioral (e.g., allodynia), functional (e.g., nerve conduction velocity), and structural (e.g., intraepidermal nerve fiber density) outcomes.Compare effects of different IF regimens (e.g., time-restricted feeding vs. alternate-day fasting).Synthesize mechanistic evidence (e.g., oxidative stress, inflammation) to bridge gaps between preclinical and clinical research.<b>Methods:</b><b>Eligibility:</b> In vivo animal studies of metabolic, toxic, or genetic neuropathy with IF interventions.<b>Data Sources:</b> PubMed, Scopus, Embase, Cochrane Library, and grey literature.<b>Risk of Bias:</b> Assessed via Cochrane Tool and Newcastle-Ottawa Scale.<b>Synthesis:</b> Meta-analysis (if feasible) or narrative synthesis, following PRISMA 2020 guidelines.<b>Significance:</b><br>This review will consolidate preclinical evidence to inform translational research, identify optimal IF protocols, and highlight limitations in current models (e.g., sex bias, chronicity). Results may guide future clinical trials for neuropathy management.<b>Keywords:</b><br>Intermittent fasting, peripheral neuropathy, neuroprotection, animal models, systematic review, oxidative stress, autophagy.