Additional file 4 of Cullin-RING ligase BioE3 reveals molecular-glue-induced neosubstrates and rewiring of the endogenous Cereblon ubiquitome
Supplementary Material 4. Fig. S4. STRING network analysis of CRBN NEDDylation-dependent substrates. Substrates defined in Figure 3c show a highly interconnected network composed of 64% of the proteins. Highly interconnected sub-clusters were derived and characterized using MCODE. Color, transparency and size of the nodes were discretely mapped to the Log2 enrichment value as indicated.
Institutions
- Ikerbasque (ES)
- University of the Basque Country (ES)
- Instituto de Salud Carlos III (ES)
- CIC bioGUNE (ES)
- Telethon Institute Of Genetics And Medicine (IT)
- University of Naples Federico II (IT)
- Universitat de Barcelona (ES)
Publication Details
- Journal
- Figshare
- Published
- 2025-01-01
- DOI
- https://doi.org/10.6084/m9.figshare.28448706
- Primary Topic
- Protein Degradation and Inhibitors
- Type
- article
- Field-Weighted Citation Impact
- 0.00