Additional file 8 of Aberrant expression of collagen type X in solid tumor stroma is associated with EMT, immunosuppressive and pro-metastatic pathways, bone marrow stromal cell signatures, and poor survival prognosis

Supplementary Material 8. Figure S8: A public single-cell and spatially resolved atlas of human breast cancers corroborates COL10A1 stromal predominance. (A–C) Spatial profiling of human breast cancer and normal tissue published by Wu et al. [97], demonstrating (A) H&E staining, (B) pathological classification, and (C) COL10A1 expression. Scale bars = 1 µm. (D and E) Single-cell COL10A1 expression across (D) all major cell types and (E) cancer-associated fibroblast (CAF) subsets in the breast cancer atlas. Data were obtained from (A–C) the UCSC Xena browser (accession Wu_Swarbrick_breast_cancer_CID44971) and (D and E) the Broad Institute Single-Cell Portal (accession SCP1039). PVL, perivascular-like cell; MSC iCAF, mesenchymal stem cell, inflammatory-like fibroblast.