Additional file 7 of γ-Secretase modulator resistance of an aggressive Alzheimer-causing presenilin mutant can be overcome in the heterozygous patient state by a set of advanced compounds

Supplementary Material 7: Figure S7. Effect of an increased dose of BPN-15606 on the secretion of Aβ in WT and PS1 L166P KI MEF cells. (A-C) Ratios of Aβ40 (A), Aβ42 (B) and Aβ43 (C) expressed as % of the sum of measured Aβ (37+38+40+42+43) from WT (WT/WT) and heterozygous (L166P/WT) or homozygous (L166P/L166P) KI MEF cells treated with DMSO or 500 nM BPN-15606 (n = 10). Aβ species were separated on Tris-Bicine urea gels and analysed by immunoblotting. The calculated ratios are presented as box-whiskers-plot.