Suaeglaucin C: a new coumaronochromone isolated from <i>Suaeda glauca</i>

A new coumaronochromone (<b>1</b>), and 12 known compounds (<b>2</b>−<b>13</b>) were isolated from the ethyl acetate part of an aqueous EtOH extract of <i>Suaeda glauca.</i> Compounds <b>5</b>−<b>8</b> and <b>12</b> effectively ameliorated pericardial edema and venous congestion in zebrafish embryos induced by verapamil hydrochloride at 50 μM. Among these, <b>8</b> exhibited superior efficacy in reducing pericardial edema compared to the positive control, Digoxin. In contrast, <b>1</b>−<b>3</b> displayed significant lethality in zebrafish embryos, with LC₅₀ values of 9.41, 39.59, and 24.47 μM, respectively. Furthermore, these three compounds showed potential cytotoxic effects on HCT116 cells at 30 and 50 μM.