<i>Jatropha tanjorensis</i> J.L.Ellis &amp; Saroja inhibited carbon tetrachloride-induced fibrogenesis in Wistar rats

<i>Jatropha tanjorensis</i> has been employed to treat various diseases. This study aimed to investigate the mode of action of <i>J. tanjorensis</i> against liver fibrogenesis induced by carbon tetrachloride (CCl₄). Liver fibrosis was induced in male Wistar rats by exposing them to CCl₄ for nine weeks. From weeks 7 to 9, <i>J. tanjorensis</i> extract was administered. The study evaluated the activities of antioxidant enzymes and lipid peroxidation (LPO) levels, expression of TGFβ1 and fibrosis-associated proteins, and liver histology. <i>J. tanjorensis</i> significantly increased the depleted antioxidant activities induced by CCl₄ while significantly reducing the elevated LPO levels caused by CCl₄. Furthermore, it downregulated the upregulation of TGFβ1 and fibrosis-associated proteins induced by CCl₄ and mitigated the liver lesions and collagen deposits resulting from CCl₄ exposure. Overall, <i>J. tanjorensis</i> alleviated liver injury and fibrogenesis by exerting its antioxidant effect and inhibition of TGFβ1.