Additional file 2 of Direct genetic transformation bypasses tumor-associated DNA methylation alterations

Additional file 2. Fig. S1: Characterization of different hyper CGI sets. Fig. S2: Methylated CGIs in healthy cell types Fig. S3: CGI hypermethylation metrics across different assays. Fig. S4: Global pan-cancer DNA methylation dynamics of melanoma models and patients. Fig. S5: Differentially methylated regions of patients or melanocyte models compared to control samples. Fig. S6: Global methylation depletion in senescence and transformation model. Fig. S7: Differentially methylated regions between tumor and healthy tissue in mouse models. Fig. S8: Transcriptional state of genes associated with hyper CGIs.

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Publication Details

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Figshare
Published
2025-01-01
DOI
https://doi.org/10.6084/m9.figshare.29595465.v1
Primary Topic
Lattice Boltzmann Simulation Studies
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article
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article

Additional file 2 of Direct genetic transformation bypasses tumor-associated DNA methylation alterations

Figshare
Lattice Boltzmann Simulation Studies
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Additional file 2 of Direct genetic transformation bypasses tumor-associated DNA methylation alterations

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Abstract

Additional file 2. Fig. S1: Characterization of different hyper CGI sets. Fig. S2: Methylated CGIs in healthy cell types Fig. S3: CGI hypermethylation metrics across different assays. Fig. S4: Global pan-cancer DNA methylation dynamics of melanoma models and patients. Fig. S5: Differentially methylated regions of patients or melanocyte models compared to control samples. Fig. S6: Global methylation depletion in senescence and transformation model. Fig. S7: Differentially methylated regions between tumor and healthy tissue in mouse models. Fig. S8: Transcriptional state of genes associated with hyper CGIs.

Figshare
Broad Institute (US), Queen Mary University of London (GB), University of Potsdam (DE), Yale University (US), Massachusetts General Hospital (US), Dana-Farber Cancer Institute (US), Max Planck Institute for Molecular Genetics (DE), Charité - Universitätsmedizin Berlin (DE)
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Lattice Boltzmann Simulation Studies
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