Additional file 2 of Integration of multi-omics data to unveil the molecular landscape and role of piRNAs in early-onset colorectal cancer

Additional file 2: Figure S1. Mutation in APC gene in CRC subgroups. Figure S2. The Spearman correlation of DNA methylation with gene expression. Figure S3. Expression pattern of PIWIL1 in different cell types and CMSs of age-of-onset colorectal cancer. Figure S4. Basal expression of FR019089, FR019019, and FR132045 in colon cell lines and efficiency verification of mimic and inhibitor. Figure S5. Effects of FR019089 and FR019019 on cellular proliferation. Figure S6. The prognostic significance of FR019019 in CRC patients. Figure S7. FR019089 and FR019019 promote the expression of TNF, RIPK3, GATA3, and PPARG.