FORMULATION AND INVITRO EVALUATION OF FLOATING TABLETS USING TAPENTADOL HCL AS A MODEL DRUG

The oral route is the predominant and most preferable route for drug delivery, but drug absorption is unsatisfactory and highly variable in the individuals despite excellent in vitro release patterns. Several approaches are currently utilized in the prolongation of the gastric residence times, including floating drug delivery systems, swelling and expanding systems, polymeric bio adhesive systems, modified-shape systems, high-density systems and other delayed gastric emptying devices. Pain is a disorder that everyone experiences. Analgesics having similar effectiveness with improved compliance in comparison to opioids are valuable additions to the analgesic armamentarium. Polymers used in the drug delivery system are of two types Natural and Synthetic based on their origin. Both types of the polymers have some advantages and disadvantages. This results in prolonged gastric retention time of floating forms which improve bioavailability of drug and also improve clinical situations. FDDS is one amongst the GRDF’s used to achieve prolonged gastric residence time. The purpose of writing this review on FDDS was to compile the recent literature with principle mechanism of floatation to achieve gastric retention. The development of FDDS including the physiology and formulation factors affecting gastric retention, classification and formulation, advantages and disadvantages are covered. This also summarizes the in vitro studies to evaluate the performance and application of FDDS. Keywords: Delayed gastric emptying devices, Analgesics, opioids, Natural and Synthetic Polymers, FDDS and GRDF.