Recommendations for planning and conducting Trials within Cohorts (TwiCs)

The aim of this booklet is to offer a comprehensive overview of the key aspects to consider while planning and conducting trials within cohorts and to provide solutions to the main challenges in developing, implementing and conducting trials within cohorts (or TwiCs). This booklet has been adapted from ERA4Health’s original document D14.2 “Recommendation booklet for investigators and sponsors in multi-country investigator initiated clinical studies”. References cited in this document can be found at the original source.