Preparation and Evaluation of oil Entrapped Gastro-Retentive Floating Gel Beads of Ondansetron HCL as Anti-Emetic

The goal of the presented work was to create a gastro-retentive floating gel beads of Ondansetron HCL.Ondansetron is a selective 5-HT3 serotonin-receptor antagonist used for its antiemetic properties. It is oneof the four FDA-approved 5-HT3 serotonin-receptor antagonists used to combat nausea and vomiting. It ismetabolised by first pass effect in liver which drastically reduces its systemic availability. Thisformulation aimed to improve drug’s bioavailability by prolonging its release for up to 12 hrs and thus itsgastric retention. A total of 6 formulations were prepared. The emulsion gelation method was used toformulate these oil entrapped floating drug beads. Each of the formulations prepared were assessed for anumber of factors i.e. morphology, floating behaviour, drug content, in vitro % cumulative drug release(%CDR). The physicochemical properties of the produced micro gel beads were found to be satisfactory.Also each of the formulated batch demonstrated satisfactory buoyancy in virto profile. Ondansetron 8 mgSlow Release Capsules from Bayview Pharmacy was taken as the standard. To compare the selectedoptimized formulation (F4) with the regular marketed formulation, various model dependent releasekinetics were used including zero and first order, models. The results showed highest data fitting to theequation of zero order model for the formulation F4 (with R2 = 0.9948), which indicated that the drugrelease followed non-Fickian diffusion mechanism.