Evaluation of anti-obesity & hypolipidemic activities of ethanolic extract of Cinnamomum zeylanicum and Morus alba

ABSTRACTIt refers the evaluation of anti-obesity and hypolipidemic activities of ethanolicextract of Cinnamomum zeylanicum and Morus alba. The fresh bark of Cinnamomumzeylanicum and leaves of Morus alba were collected from UP East region andauthenticated from a botanist. Bark of Cinnamomum zeylanicum was extractedthrough Soxhlet and leaves of Morus alba extracted through maceration process usingethanol. The albino rats were obtained from the Animal House, Saraswati HigherEducation and Technical College of Pharmacy, Gahni, Ayar, Varanasi; kept at temp.25±1°C with 12-hour light/dark cycle. Animals were kept into 5 groups; n=6 i.e.,group 1: normal saline; group 2: high fat diet (HFD) + normal saline; group 3: HFD +Cinnamomum zeylanicum (400mg/kg); group 4: HFD + Morus alba (400mg/kg) for15 days and group 5 given HFD + Orlistat (50mg/kg) for 15 days. The blood sugarlevel was estimated at the day 1, 3, 5, 10 & 15. The HFD + Cinnamomum zeylanicum(400mg/kg) treated animals showed the blood glucose level as 90.43±0.42mg/dl,92.20±0.23mg/dl and 94.20±0.34mg/dl, at the day 5, day 10 and day 15, respectively.However, HFD + Morus alba (400mg/kg) treated rats showed the blood glucose levelas 91.45±0.64mg/dl, 94.46±0.25mg/dl and 96.20±0.12mg/dl, respectively. This studysuggests that Cinnamomum zeylanicum and Morus alba medication may berecommended as a well recognised treatment for obesity management and cholesterolreduction, thereby improving overall health and extending lifespan.