Effects of Chemohormonal Therapy on Oxidant and Antioxidant Systems in Patients with Metastatic Castration- Resistant Prostate Cancer

Objective: The aim of this study was to investigate the effects of chemohormonal therapy on catalase (CAT), superoxide dismutase (SOD), glutathione (GSH), glutathione peroxidase (GPx), arylesterase (ARE), paraoxonase (PON), myeloperoxidase (MPO), malondialdehyde (MDA), total antioxidant status (TAS), total oxidant status (TOS) in patients with metastatic castration-resistant prostate cancer (MCCRPC). The aim of this study was to investigate the effect of chemohormonal treatment and treatment resistance on oxidant and antioxidant system in cancer and prostate cancer through oxidative stress index (OSI) parameters and to show that it may have a predictive value in the diagnosis, prognosis and treatment of the disease. Material and method: This study included 112 patients diagnosed with prostate cancer and 30 healthy individuals (control group) who were admitted to the Departments of Medical Oncology and Radiation Oncology of Atatürk University Medical Faculty Hospital. Patients were divided into four groups according to the treatment protocol. Patients received androgen suppression therapy, secondary hormone therapy and non-hormone therapy (chemoteropathic drugs) respectively (as resistance developed). The first group was sensitive to androgen suppression therapy (ADT), the second group was resistant to androgen suppression therapy and sensitive to chemotherapeutic agents. The third group was the group that developed resistance to chemotherapeutics. The fourth group was patients who were diagnosed with prostate cancer and did not receive treatment. CAT, SOD, tGSH, GPx, GPx, ARE, PON, MPO and MDA levels were analyzed by manual antioxidant methods in patient and control serum samples, while TAS, TOS and OSI levels were analyzed by commercially purchased kits and according to the Erel method. Results: CAT, ARE, MPO, TAS, TOS and OSI parameters showed significant differences between the groups (p<0.05), while SOD, tGSH, GPx, MDA and PON parameters showed no significant differences between the groups. Conclusion: This is a research study that will shed light on the effects of chemohormonal therapy and treatment resistance on oxidant and antioxidant systems in cancer and prostate cancer and will fill the gap in the literature.