FORMULATION AND EVALUATION OF ANTIOXIDANT HERBAL GEL FROM PYRUS COMMUNIS

The present project has been undertaken with the aim to formulate and evaluate of polyherbal gel containing Pear (Pyrus communis), Orange (Citrus sinensis) and Alovera (Aloe barbadensis) as a cleansing agent, anti-acne and skin nourishing. Natural remedies are believed to be more acceptable in the way that they are suffer with fewer side effects than the synthetic ones. Herbal formulation has growing demand in the world market. The plant has been reported in literature having good antimicrobial, anti-inflammatory, refreshing activity, cleansing agent and anti-oxidant. The formulations are prepared by using varied types of concentration of extract prepared formulation which are evaluated for various parameters like color, appearance, consistency, washability, pH and Spreadability, Extrudabilty, skin irritation and compared with marketed formulation. It has a wide spectrum of antioxidant activity against acne prone skin. The prepare gel is formulated by using propyl paraben as gelling agent, herbal extracts are the medicinal agents in formulation. Hydroxypropyl methylcellulose is used as a co-solvent, sodium benzoate as a preservative and required quantity of distilled water as a vehicle. On the basis of the results obtained in the present study we conclude that the gel formulation of polyherbal contents showed good activities towards the declared evaluations. Herbal drugs have great growth potential in the global market and natural product research continues to explore traditional medicines to develop new novel drugs system. The present study aimed to investigate antioxidant potential of gel formulated with Pyrus communis peel extract and Citrus sinensis peel extract. Citrus sinensis is one of the extensively studied plants in the Rutaceae family and is a popular and commonly used ingredient in Traditional Chinese Medicine with preparations derived from peels, young fruit, mature fruit, flower, and other tissues. The plant is also known for numerous activities such as antioxidant, antibacterial, ant diabetic, antifungal, ant osteoporosis, hypocholesterolemic, ant obesity, etc. due to the presence of phenolic acids, flavonoids, and essential oil components.