Evaluation Of the Anti Fibroid Potential of the Seeds of Sorghum Bicolor (L.) Monench, Poaceae on Monosodium Glutamate-Induced Uterine Fibroid in Wister Rats

Introduction: Sorghum is a staple food in Africa and many parts of the world yet with significant medicinal value. This study aims at assessing the anti-fibroid effect of Sorghum bicolor powder in Wistar rats. Methods: Dried seed of Sorghum bicolor was purchased and powdered. Phytochemical screening was conducted on the powder using standard methods. The powder was assessed for acute toxicity in rats. Groups of rats were induced orally with Monosodium glutamate (100 mg/kg) for 30 days and then treated with the powder at 400mg/kg, 800mg/kg and 1200mg/kg for thirty days. Danazol (200mg/kg) was used as standard drug. The weight ratio of the uterus to the weight of the rats, the estradiol, albumin, liver enzymes, kidney and total protein were assessed using standard kits after the rats were sacrificed on the 30th day. Results: Phytochemical screening revealed the presence of alkaloid, triterpenoid, steroids, flavonoids and tannins. Acute toxicity showed Median Lethal Dose (LD50) of 5000mg/kg. The uterine to weight ratio and the estradiol of the treated rats were significantly decreased in a dose dependent manner. No significant effect was observed in the albumin, liver enzymes, kidney and the protein of the treated groups. Conclusion: The Sorghum powder is safe at 5000mg/kg. Biochemical analysis shows reduced level of estradiol and albumin as wells total protein. The study therefore supports its use in combination with other plants in treating uterine fibroid.