FORMULATION AND EVALUATION OF IMMEDIATE RELEASE TABLETS OF CLOBAZAM BY USING WET GRANULATION METHOD

An Orally disintegrating tablet disperses readily in saliva and the drug is available in solution or suspension form for the immediate absorption and resulting in rapid onset of action. In the present research work Clobazam Orally disintegrating tablet were prepared by intra and extra granulation technique method using varying concentrations of Fenugreek Gum, Karaya Gum and Crospovidoneas super disintegrants. The formulations prepared were evaluated for precompression & post compression parameters. Form the drug excipient compatibility studies we observe that there are no interactions between the pure drug (Clobazam) and optimized formulation (Clobazam + excipients) which indicates there are no physical changes. Post compression parameters was found to be within the limits. Among the formulation prepared the tablet containing concentration of Crospovidone shows 99.72% of the drug release within 60 min & follows first order kinetics. The overall result indicated that the formulation F12 containing Crospovidone is better and fulfilling of the needs of the Orally disintegrating tablet. Crucial words: Orally disintegrating tablet, Clobazam, Crospovidone, FTIR.