Association Of Hormonal Dysregulation With Pcos In Fertile Women

OBJECTIVE: To investigate the association of hormonal dysregulation with the presence of PCOS in fertile women To compare biochemical parameters such as serum FSH, LH, prolactin, testosterone, serum fasting levels, serum insulin levels and HbA1c in PCOS diagnosed group, predisposed group and control group. STUDY DESIGN: Case Control Study PLACE AND DURATION OF STUDY: This study was conducted in Obstetrics and gynaecological department of Shifa hospital, Karachi from December 2022 to June 2023. METHODOLOGY: This case-control study included 105 patients from 3 different groups; PCOS diagnosed group, healthy group, and the predisposed group. Patients assessed in the obstetrics and gynecology outpatient department were sent for lab tests, including FSH, LH, prolactin, testosterone, fasting blood sugar, insulin, and HbA1c. Blood samples were collected during the follicular phase and analyzed at PNS Shifa hospital. One way Anova test was applied for qualitative variables variables. P value < 0.05 was considered statistically significant. RESULTS: The study included 105 participants with a mean age of 28.21 years. Significant differences were found among study groups for BMI, FSH, LH, LH:FSH ratio, testosterone, prolactin, fasting blood glucose, fasting insulin, and HbA1c levels, indicating notable biochemical variations associated with PCOS status. CONCLUSIONS: The study concludes a significant association between hormonal imbalances and PCOS in both fertile and infertile women, emphasizing the importance of targeted hormonal assessment and management for all PCOS patients to enhance overall health outcomes.