Synthesis, Mechanism of action And Characterization of Sulphonamide

One of the first synthetic antimicrobials, sulfonamides, were essential to the creation of contemporary chemotherapy. These substances, which were first used in the 1930s, transformed the way bacterial infections were treated and set the stage for the later discovery of antibiotics. Beyond their historical relevance, sulfonamides' structural diversity and wide range of pharmacological potential continue to pique research attention. The chemical structure, modes of action, production methods, and a variety of biological functions of sulfonamides are all covered in detail in this article. The study also looks at new therapeutic uses that go beyond antibacterial ones, such as anti-inflammatory, anticancer, and antidiabetic effects. There is also discussion of recent developments in overcoming resistance and improving efficacy through structural alterations and innovative drug delivery methods. This study emphasizes the continued significance and potential of sulfonamide molecules in pharmaceutical sciences by reexamining both traditional and modern.

Publication Details

Journal
Zenodo (CERN European Organization for Nuclear Research)
Published
2025-05-18
DOI
https://doi.org/10.5281/zenodo.15458257
Primary Topic
Enzyme function and inhibition
Type
article
Field-Weighted Citation Impact
0.00
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article

Synthesis, Mechanism of action And Characterization of Sulphonamide

Zenodo (CERN European Organization for Nuclear Research)
Enzyme function and inhibition
article

Synthesis, Mechanism of action And Characterization of Sulphonamide

article en

Abstract

One of the first synthetic antimicrobials, sulfonamides, were essential to the creation of contemporary chemotherapy. These substances, which were first used in the 1930s, transformed the way bacterial infections were treated and set the stage for the later discovery of antibiotics. Beyond their historical relevance, sulfonamides' structural diversity and wide range of pharmacological potential continue to pique research attention. The chemical structure, modes of action, production methods, and a variety of biological functions of sulfonamides are all covered in detail in this article. The study also looks at new therapeutic uses that go beyond antibacterial ones, such as anti-inflammatory, anticancer, and antidiabetic effects. There is also discussion of recent developments in overcoming resistance and improving efficacy through structural alterations and innovative drug delivery methods. This study emphasizes the continued significance and potential of sulfonamide molecules in pharmaceutical sciences by reexamining both traditional and modern.

Zenodo (CERN European Organization for Nuclear Research)
Good health and well-being
Openalex Percentile: Top 53%
Enzyme function and inhibition
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