Pharmacoepigenomic impact of antihypertensive drugs on miRome and proteome and its potential impact on health and side effects

SUPPLEMENTARY FIGURES: Figure S1: Methodology flow chart Figure S2: MTT assay showing cell viability for different drug concentrations and time points SUPPLEMENTARY TABLES: Table S1: Significantly regulated miRNAs (P-values < 0.05) with the respective fold change Table S2: The validated target genes (3' UTR binding, binding score ≥ 0.95) derived from miRwalk database Table S3: Validated miRNA target genes associated with Hypertension Table S4: Validated miRNA target genes and the side effects associated in terms of HPO database Table S5: Significantly differentially regulated proteins

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Publication Details

Journal
Zenodo (CERN European Organization for Nuclear Research)
Published
2025-07-30
DOI
https://doi.org/10.5281/zenodo.16579433
Primary Topic
MicroRNA in disease regulation
Type
article
Field-Weighted Citation Impact
0.00
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article

Pharmacoepigenomic impact of antihypertensive drugs on miRome and proteome and its potential impact on health and side effects

Zenodo (CERN European Organization for Nuclear Research)
MicroRNA in disease regulation
article

Pharmacoepigenomic impact of antihypertensive drugs on miRome and proteome and its potential impact on health and side effects

article en

Abstract

SUPPLEMENTARY FIGURES: Figure S1: Methodology flow chart Figure S2: MTT assay showing cell viability for different drug concentrations and time points SUPPLEMENTARY TABLES: Table S1: Significantly regulated miRNAs (P-values < 0.05) with the respective fold change Table S2: The validated target genes (3' UTR binding, binding score ≥ 0.95) derived from miRwalk database Table S3: Validated miRNA target genes associated with Hypertension Table S4: Validated miRNA target genes and the side effects associated in terms of HPO database Table S5: Significantly differentially regulated proteins

Zenodo (CERN European Organization for Nuclear Research)
Rajiv Gandhi Centre for Biotechnology (IN)
Good health and well-being
Openalex Percentile: Top 44%
MicroRNA in disease regulation
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