Physicochemical Comparison of Pharmaceuticial Powders and Granules

A The present study involves a comparative analysis of powders and granules formulated using a BCS Class I drug, which is characterized by high solubility and high permeability. The objective of the study is to evaluate and compare the physicochemical properties, flow behavior, and drug release profiles of the two formulations. Preformulation parameters such as angle of repose, bulk density, tapped density, Carr’s index, and Hausner ratio were assessed to determine flow characteristics. In addition, in vitro dissolution studies were conducted to analyze drug release patterns. The results indicated that granules exhibited improved flow properties and better compressibility compared to powders, contributing to enhanced uniformity and processability in tablet manufacturing. Drug release from both forms was comparable due to the inherent solubility of the BCS Class I drug. The study concludes that granulation is a preferred technique for improving handling and processing characteristics without compromising drug release efficiency.