Formulation And Evaluation of a Itraconazole Nanosponges

Itraconazole (ITZ), an antifungal drug, faces challenges related to poor water solubility, leading to low bioavailability. This study aimed to formulate and evaluate ITZ-loaded nanosponges to enhance its solubility and therapeutic efficacy. Nanosponges were prepared using the emulsion solvent diffusion method, employing different ratios of drug, polymer (e.g., ethylcellulose), and porogen (e.g., polyvinyl alcohol). The prepared nanosponges were characterized for particle size, entrapment efficiency, drug loading, in vitro drug release, and Smorphology. The optimized formulation exhibited a particle size in the nanometer range, high entrapment efficiency, and sustained drug release. In vitro studies demonstrated improved dissolution of ITZ from the nanosponges compared to the pure drug. The results suggest that ITZ-loaded nanosponges could be a promising approach to improve the solubility, dissolution, and bioavailability of ITZ, potentially leading to enhanced antifungal activity. Itraconazole, a broad-spectrum antifungal agent, exhibits poor water solubility and limited oral bioavailability, posing significant challenges in achieving effective therapeutic concentrations. To overcome these limitations, the present study focuses on the formulation and evaluation of itraconazole-loaded Various formulations were developed and optimized based on particle size, drug entrapment efficiency, and in vitro drug release. nanosponges aimed at enhancing solubility, controlled drug release, and improved bioavailability.