PATHOMORPHOLOGY AND IMMUNOGISTOCHEMISTRY OF LEIOMYOMATOUS HAMARTOMA OF THE LUNGS

Abstract. The article studies the morphogenesis, pathomorphology and immunohistochemical aspects of leiomyomatous hamartoma of the lung. The objects of study were pulmonary hamartomas examined in the biopsy diagnostics department of the RPAM during 2014-2024. Lung hamartoma has a microscopically polymorphic structure, mainly consisting of bundles of smooth muscles located in different directions, a small amount of fibrosis, adipose tissue, epithelial cells that have undergone various metaplastic and dysplastic changes, located between them, covering the gaps. The marker desmin, which determines the level of differentiation of mesenchymal cells, is expressed in leiomyomatous hamartoma by an average of 17.4%; positive staining of the sarcoplasm and sarcomeres of cells confirms that this marker is localized in myosin, endoplasmic reticulum and mitochondria. Vimentin is located in the intermediate filament of mesenchymal cells, occupies a place in the nucleus, endoplasmic reticulum and mitochondria, is expressed in both the nucleus and sarcoplasm of smooth muscle cells, and is important for maintaining cell shape and providing resistance. to mechanical stress.