Efficacy and Mechanisms of Karanja Ghrita in Wound Healing: An Ayurvedic Perspective

Abstract Introduction: Wound healing is a critical process in clinical care, where traditional therapies, such as those derived from Ayurveda, offer significant benefits. Karanja Ghrita, a formulation combining Karanja (Pongamia pinnata) oil and ghee, is traditionally used in Ayurvedic practices for its wound healing properties. This review explores its efficacy and underlying mechanisms in wound management. Methods: The paper examines the Ayurvedic principles of wound healing, which include the stages of dushta vrana (septic wound), shudh vrana (clean wound), roohyamana vrana (healing wound), and roodha vrana (healed wound). Emphasis is placed on the role of Karanja Ghrita in each phase of healing and its application in clinical settings. Results: Karanja Ghrita demonstrates significant therapeutic potential in wound healing. It acts through its antimicrobial, anti-inflammatory, and analgesic properties, promoting both wound purification (vrana shodhana) and healing (vrana roopana). The formulation enhances tissue regeneration, prevents infection, and accelerates wound closure, particularly in chronic and septic wounds. Discussion and Conclusion: The clinical benefits of Karanja Ghrita in wound healing extend beyond its traditional use, supported by its bioactive compounds. Its ability to support tissue regeneration, reduce inflammation, and prevent infections makes it a valuable adjunct in both acute and chronic wound care. By integrating Ayurvedic formulations like Karanja Ghrita with modern wound management, healthcare practitioners can offer holistic, effective treatments for various wound types. Keywords: Karanja Ghrita, Wound Healing, Ayurvedic Formulations, Vrana Shodhana, Chronic Wounds