Comparative Study of Normal Progression of Labour Vs use of Injection Drotaverine Hydrochloride and Injection Valethamate Bromide on Cervical Dilatation and Progression of Labour

Objective: To compare the normal progression of labour vs use of injection Drotaverine Hydrochloride and injection Valethamate Bromide on cervical dilatation and progression of labour.  Method: This prospective randomised study was conducted in obstetrics and gynecology department at Navodaya Medical College Hospital and Research Centre , Raichur involved 100 pregnant women admitted to labour room for delivery during the study period of one year . Written informed consent was taken. After taking history, general and obstetrics examination was done and contracted pelvis was ruled out. Group I included 50 pregnant women (n=50) who were allowed for spontaneous progression of labour. Group II included 50 pregnant women(n=50) who received injection Drotaverine hydrochloride and injection valethamate bromide and effect on cervical dilatation and progression of labour was noted and compared.  Results: The mean rate of cervical dilatation was 1.2cm/hr in primigravida and 1.5cm/hr in multigravida in group I compared to group II with mean rate of cervical dilatation in primigravida is 2.8cm/hr and 3.5cm/hr in multigravida which is statsically significant (p <0.01) In group I the mean duration of active phase of labour in primigravida was 197 mins and 178 minutes in multigravida compared to 98 minutes un primigravida and 81 minutes in multigravida in group II which is statistically significant (p value <0.01) . there was no statiscally significant difference found in two groups with respect to mode of delivery (p=0.835)  Conclusion: Comparison of cervical dilatation rates and progression of labour revealed a significant acceleration in the drug group, surpassing the control group.