A Brief Review on Sustained Release Matrix Tablets

To improve patient compliance, reduce the frequency of dose, and maintain constant drug plasma levels, sustained-release matrix tablets are a cutting-edge drug delivery method that releases therapeutic agents over an extended period. The principles, formulation techniques, and assessment methodologies related to sustained-release matrix tablets are all thoroughly covered in this paper. The notion of sustained release systems is introduced at the outset, with an emphasis on its benefits over traditional dose forms, especially in the treatment of chronic illnesses. The presentation includes a thorough explanation of formulation methods, such as wet granulation, direct compression, and new technologies like 3D printing and hot-melt extrusion. The paper also discusses evaluation techniques in vitro and in vivo, with an emphasis on drug release kinetics and pharmacokinetic characteristics that are essential for the creation of these systems. Recent developments in the field are also highlighted in the study, such as the utilization of pulsatile release devices, nanotechnology, and microparticles for improved drug delivery. In summary, further research into novel materials and customized delivery methods will continue to influence the future of sustained-release matrix tablets in pharmaceutical science, even if they have achieved great strides in therapeutic applications. Researchers and formulators working on the creation of sustained-release matrix systems will find this review to be a useful resource.