The 3 Rs Of Replication-Competent Lentivirus (RCL) Formation Risk: Real, Rare or Artificial?

A mathematical model for RCL formation from 3rd generation LV systems. The associated .html file presents a mathematical model for calculating the probability of replication-competent lentivirus (RCL) formation in lentiviral vector (LV) manufacturing. User inputs update the model to adjust for custom bioreactor volumes, production cell type (transient/packaging), plasmid ratios and recombination rates.

Publication Details

Journal
Zenodo (CERN European Organization for Nuclear Research)
Published
2025-03-25
DOI
https://doi.org/10.5281/zenodo.15081754
Primary Topic
Virus-based gene therapy research
Type
article
Field-Weighted Citation Impact
0.00
Controls
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article

The 3 Rs Of Replication-Competent Lentivirus (RCL) Formation Risk: Real, Rare or Artificial?

Zenodo (CERN European Organization for Nuclear Research)
Virus-based gene therapy research
article

The 3 Rs Of Replication-Competent Lentivirus (RCL) Formation Risk: Real, Rare or Artificial?

article en

Abstract

A mathematical model for RCL formation from 3rd generation LV systems. The associated .html file presents a mathematical model for calculating the probability of replication-competent lentivirus (RCL) formation in lentiviral vector (LV) manufacturing. User inputs update the model to adjust for custom bioreactor volumes, production cell type (transient/packaging), plasmid ratios and recombination rates.

Zenodo (CERN European Organization for Nuclear Research)
Openalex Percentile: Top 47%
Virus-based gene therapy research
DOIOpen Access PDFOpenAlex
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The 3 Rs Of Replication-Competent Lentivirus (RCL) Formation Risk: Real, Rare or Artificial? · Zenodo (CERN European Organization for Nuclear Research) (2025) | TGRS Research Map | TGRS