Investigation of Factors Affecting the Formation of Secondary Non-Traumatic Fractures Due to Mineral Bone Disorder in Hemodialysis Patients: A Single-Center Experience

Background: In our study, we aimed to determine whether demographic data and biochemical parameters of patients undergoing hemodialysis influence the prediction of secondary non-traumatic fractures due to mineral bone disorder caused by chronic kidney disease. Methods: This cross-sectional study was conducted by retrospectively scanning the records of patients aged 18 years and older who had undergone hemodialysis for at least six months at our hospital’s hemodialysis unit between 2017 and 2022. A total of 272 patients meeting the inclusion criteria were examined through hospital records. Results: Of the 272 patients included in the study, 57.7% were males, and the median age was 65 years. Non-traumatic fractures were detected in 32 (11.8%) patients. Non-traumatic fractures were significantly more common in female patients compared to males (18.3% vs. 7%; p=0.008). Eight patients had undergone parathyroidectomy, and among them, non-traumatic fractures were significantly more frequent compared to those who had not undergone the procedure (50% vs. 10.6%; p=0.008). Patients using steroids had significantly more non-traumatic fractures compared to non-users (26.9% vs. 10.2%; p=0.021). The duration of dialysis was significantly longer in patients with non-traumatic fractures compared to those without (60.5 months [7 - 324] vs. 39.5 months [7 - 330]; p=0.017). The risk of non-traumatic fractures was found to be 3.66 times higher in women, 4.17 times higher in steroid users, and increased by 0.7% with each additional month of dialysis. Conclusion: This study investigated factors influencing non-traumatic fractures associated with mineral bone disorder in hemodialysis patients. Female gender, steroid use, parathyroidectomy, and dialysis duration were found to increase the risk of fractures. No significant association was found between fractures and other laboratory parameters or medications used by patients to regulate bone mineral metabolism.