Transethosomes: Vesicular Carriers in Transdermal Drug Delivery Systems - A Review

Transdermal drug delivery is a good substitute for oral administration, particularly for medications that have low bioavailability because of gastrointestinal problems or first-pass metabolism. Ultra-deformable lipid vesicles called transethosomes are intended to improve transdermal medication administration by enhancing skin penetration and prolonging drug release. Transethosomes, which are made up of phospholipids, ethanol, stabilizers, edge activators, and water, encapsulate hydrophilic and lipophilic medications, improving therapeutic effectiveness and minimizing adverse effects. Because of their great flexibility, they can move across the stratum corneum with the help of ethanol-induced lipid fluidization. Vesicle characteristics are influenced by a variety of preparation techniques, including thin film hydration and ethanol injection-sonication. Evaluation parameters include morphology, zeta potential, entrapment efficiency and drug release studies. Despite minor disadvantage like potential skin irritation, Transethosomes provide promising benefits in controlled and non-invasive drug delivery.