HYPERTENSION, KIDNEY FUNCTION AND NON-ALCOHOLIC FATTY LIVER DISEASE IN TYPE II DIABETES

Abstract: Background: Non-Alcoholic fatty liver disease (NAFLD) is common in type 2 diabetes and can worsen to serious liver damage. The connection between these two conditions highlights the need for combined treatment approaches. This article assesses the relationship between Non-Alcoholic Fatty Liver Disease, and some clinical factors in the context of Type II diabetes. Method: The study was carried out at the University of Port Harcourt Teaching Hospital (UPTH), Rivers State, Nigeria. The study included 300 participants aged 18 and above, consisting of 150 diabetic patients and 150 age- and sex-matched controls. Participants underwent clinical, biochemical, and anthropometric assessments. Blood samples were collected to analyse liver enzymes, glucose, and lipid profiles according to standard laboratory procedures. Additionally, all subjects received abdominal ultrasound examinations to detect hepatic steatosis, indicative of NAFLD. Results: There was a 32.7% prevalence of NAFLD among the diabetic patients. Normal kidney function is observed in 53.1% of the NAFLD group and 49.5% of the non-NAFLD group. Mild reduction in kidney function appears in 32.7% of the NAFLD group and 35.6% of the non-NAFLD group. Moderate to severe reductions in kidney function show comparable rates across both groups, and these differences are not statistically significant (p = 0.939).Hypertension is more prevalent among those with NAFLD, with 30.6% of these individuals affected compared to 16.8% of those without NAFLD. Although this trend suggests a higher occurrence of hypertension in the NAFLD group, the difference is only marginally significant (p = 0.053). Conclusion: There were no significant differences in the distribution of hypertension and kidney function among persons with NAFLD. However, these findings emphasize the need for a comprehensive approach to management, encompassing strategies to improve glycaemic control, monitor kidney function, manage blood pressure effectively, and promote healthy weight management. Keywords: NAFLD, Diabetes Mellitus (DM), Glucose control, BMI, Hypertension. Title: HYPERTENSION, KIDNEY FUNCTION AND NON-ALCOHOLIC FATTY LIVER DISEASE IN TYPE II DIABETES Author: Owamagbe E. M., Kiyesi A. L., Ogamba M. I. International Journal of Novel Research in Healthcare and Nursing ISSN 2394-7330 Vol. 12, Issue 2, May 2025 - August 2025 Page No: 176-183 Novelty Journals Website: www.noveltyjournals.com Published Date: 11-August-2025 DOI: https://doi.org/10.5281/zenodo.16793409 Paper Download Link (Source) https://www.noveltyjournals.com/upload/paper/HYPERTENSION,%20KIDNEY%20FUNCTION-11082025-4.pdf