Development of a Bio-Enhanced Herbal Antidiabetic Tablet Using Gymnema sylvestre

The present study focuses on the formulation and evaluation of herbal tablets containing Gymnema sylvestre, a medicinal plant known for its antidiabetic and hypoglycemic properties. The objective was to develop a stable, effective oral dosage form using the dried leaf powder of Gymnema sylvestre and to evaluate its physicochemical properties and dissolution profile. Tablets were prepared by direct compression using various excipients including microcrystalline cellulose, lactose, calcium carbonate, stearic acid, and magnesium stearate. Three different batches were formulated and evaluated for pre-compression parameters such as bulk density, tapped density, Carr's index, Hausner’s ratio, and angle of repose, which indicated good flow properties. Post-compression studies included weight variation, hardness, friability, disintegration time, wetting time, and dissolution testing. Batch 3, Higher concentration of Gymnema sylvestre, showed superior mechanical strength, better dissolution rate, and improved tablet characteristics. A UV spectrophotometric method was also developed. The study successfully demonstrates the potential of Gymnema sylvestre as a natural therapeutic agent in tablet form and provides a basis for future development of standardized herbal formulations.