FORMULATION AND EVALUATION OF RATE RETARDING POLYMERS IN THE PROLONGED RELEASE TABLETS OF LOVASTATIN

Abstract The aim of the present study was to develop Lovastatin extended release tablets to maintain constant therapeutic levels of the drug for over 12hrs. Gum Acacia, Almond gum and Grewia gum were used as polymers. All the formulations were passed various physic chemical evaluation parameters such as bulk density, tapped density, cars index, hausners ratio, angle of repose , weight variation, hardness, thickness, friability and drug content. From the dissolution studies it was evident that the formulation F9 showed better and desired drug release pattern i.e., 98.82% in12 hours. It contains the Grewia gumas polymer. It followed Higuchi release kinetics mechanism. Keywords: Lovastatin, Gum Acacia, Almond gum, Grewia gum and Extended Release Tablets.