Formulation And Evaluation of Mouth Dissolving Film of Losartan Potassium

Nine fast-dissolving film formulations of Losartan Potassium were successfully developed using the solvent casting method, incorporating various grades of Hydroxypropyl Methylcellulose (HPMC E5, E15, and E50) along with film modifiers to improve mechanical and physicochemical properties. The films were uniformly thin, flexible, elastic, smooth, and transparent, with consistent weights ranging from 16.14 ± 0.192 mg to 17.31 ± 0.313 mg, indicating reproducible formulation. Mechanical evaluation showed folding endurance values exceeding 150 folds across all formulations, confirming excellent flexibility and durability. Drug content analysis demonstrated uniform distribution of Losartan Potassium in the polymer matrix. In vitro dissolution studies revealed rapid drug release, with over 90% released within 5 minutes for all formulations. Notably, formulation F2 exhibited the highest release at 98.73% within the same timeframe. Based on drug release, uniformity, and disintegration performance, F2 was identified as the most promising formulation. Stability testing under accelerated conditions (40°C and 75% RH) showed no significant changes, confirming the films' physical and chemical stability. A comparative study with the marketed tablet LOSAR-25 highlighted the superior performance of F2, which released 98.73% of the drug in 4 minutes, while LOSAR-25 achieved only 90.76% release in 30 minutes. These findings suggest the developed films, particularly F2, offer rapid onset of action and improved drug delivery over conventional tablets. However, further in vivo studies are needed to confirm clinical efficacy and therapeutic advantage.