Formulation And Evaluation of Bi-Layered Tablet of Divalproex Sodium

The pharmacokinetic advantage relies on the criterion that, drug release from the fast-releasing layer leads to a sudden rise in the blood concentration. However, the blood level is maintained at steady state as the release from sustained layer. Particularly bilayer tablets are commonly used to avoid chemical incompatibilities of formulation components by physical separation, and release profile. The tablet is the most widely used dosage form because of its convenience in terms of self-administration, compactness and ease in manufacturing.4 Tablets are solid dosage forms containing medicinal substances with or without suitable diluents.5 According to Indian Pharmacopoeia Pharmaceutical tablets are solid, flat or biconvex dishes, unit dosage form, prepared by compressing a drugs or a mixture of drugs, with or without diluents.6 They are varying in size and weight, depending on amount of medicinal substances and the intended mode of administration. It is most popular dosage form and 70% of the total medicines are dispensed in the form of tablet There are different types of tablets are available in market conventional tablet, immediate tablet, fast dissolving tablet, controlled release tablet, sustained release tablet, delayed release tablet.Immediate release tablets are those which disintegrate rapidly and get dissolved to release the medicaments.10 For immediate release formulation, super disintegrants play key component. Super disintegrants are used to improve the efficacy of solid dosage form. This achieved by various mechanisms, swelling, porosity and capillary action, heat of wetting, particle repulsion forces, deformation recovery, enzymatic reaction by which the tablets are broken into small particles.