Formulation Development and Evaluation of Paracetamol and Ibuprofen Bilayer Tablet

In order to maximize pain treatment through different release profiles, the study describes the creation and assessment of bilayer tablets that combine sustained-release ibuprofen and immediate-release paracetamol. The physical properties of several formulations, including their total density, pressed density, angle of repose, Carr's index, and Hausner ratio, were generated and assessed using wet granulation for paracetamol and dry granulation for ibuprofen. Compression was followed by evaluations of tablet toughness, thickness, weight deviation, friability, disintegration time, and in vitro dissolution tests. The findings showed that formulation F6, which included sodium starch glycolate for paracetamol and HPMC K4M with sodium alginate for ibuprofen, met dissolving criteria and had the best release characteristics. This formulation approach highlights the potential of bilayer tablets in improving therapeutic outcomes in pain management by efficiently utilizing the synergistic effects of both medications, offering a quick onset of pain relief together with a prolonged anti-inflammatory action.