Design, Synthesis and Evaluate Antioxidant, Antibacterial and Antiinflammatory activity of Some Apigenin Derivatives

ABSTRACTSome novel Apigenin derivatives (03) were synthesized in good yields and evaluated for their possibleantibacterial, antioxidant, and anti-inflammatory activities. The structures of the synthesizedcompounds were confirmed based on their spectral data and elemental analysis. Their antibacterialactivities were evaluated by the agar well diffusion method while their antioxidant potential wasexamined in vitro by use of three tests: 2.2-diphenyl-1-picrilhidrazil (DPPH). Anti-inflammatoryactivities were evaluated by the carrageenan-induced hind paw edema test. All the tested compoundsshowed considerable antibacterial activities and antioxidant activities with high to moderate anti-inflammatory activities that last for 12 h compared to ibuprofen. All the tested compounds showed notoxic symptoms or mortality rates 24 h post-administration at tested anti-inflammatory doses. Inaddition, LD50 for all tested compounds was higher than that for ibuprofen implying their good safetymargin. The obtained results showed that the most active compounds could be useful as a template forfuture design, modification, and investigation to produce more active analogs.