Evaluating The Therapeutic Potential Of Garcinia Gummi-Gutta

The study examines the phytochemical content and therapeutic properties of methanolic extracts from the rind and fruit of G. gummi-gutta. Both qualitative and quantitative analyses revealed the presence of flavonoids, alkaloids, tannins, and phenols in the rind, and flavonoids and tannins in the fruit. The therapeutic properties like anti-oxidant, anti-diabetic, anti-cancer, anti-inflammatory, wound healing, anti-ulcer, and anti-microbial were determined using DPPH assay, α-amylase inhibition assay, MTT assay, protein denaturation assay, wound scratch assay, acid neutralizing capacity method, and agar well diffusion method respectively. Results showed that anti-oxidant and anti-diabetic activities increased with extract concentration. The rind extract exhibited significant anti-cancer activity, with a 32.08% inhibition of MCF-7 cell lines at 100 and 200µg/mL. The anti-inflammatory effect was higher in the rind (79.35%) than in the fruit (58.04%) at 100µg/mL. The wound healing effect was greatest at 50 µg/mL with 87.45% closure. Anti-ulcer activity decreased with higher extract concentrations. Both extracts showed anti-microbial activity against bacteria, though not against fungi. The rind extract generally demonstrated greater therapeutic potential than the fruit extract.