Titrimetric Analysis of Bulk Drug Salicylic Acid Using Hydrotropic Solubilization Method

One of the enhancement techniques is hydrotropic solubilization, which uses hydrotropes like sodium citrate, sodium benzoate, urea, etc., to greatly increase solubility. This method has several advantages, such as not requiring organic solvents, chemically modifying hydrophobic drugs, or preparing emulsion systems.This study aims to use hydrotropy to a specific problem: how to make the medicine ibuprofen more soluble in 0.1 M ammonium acetate.Ionic organic salts considered as hydrotropic agent.These days, hydrotropic agents are being utilized to increase the therapeutic efficiency and bioavailability of poorly water-soluble pharmaceuticals by generating a variety of dosage forms, such as injections, mouth-dissolving tablets, and solid dispersions.